Different steps of the oxidative decarboxylation of pyruvate by the pyruvate dehydrogenase PDH complex are given. Place these five steps in the correct order. Note that thiamine pyrophosphate, TPP, is sometimes called thiamine diphosphate, TDP.
1. FADH2 is reoxidized to FAD reducing NAD* to NADH.
2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.
3. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.
4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.
5. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

Answers

Answer 1

Answer:

1. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.

2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.

3. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.

5. FADH2 is reoxidized to FAD reducing NAD+ to NADH.

Explanation:

The oxidation of pyruvate to AcetylCoA is catalyzed by the pyruvate dehydrogenase complex. The reaction is an irreversible oxidative decarboxylation process in which the carboxyl group of pyruvate is removed as a molecule of carbon dioxide, CO₂, while the remaining two carbons are attached to a CoASH molecule to form acetylCoA.

The pyruvate dehydrogenase complex contains three enzymes - Pyruvate dehydrogenase known as E₁, dihydrolipoyl transacetylase known as E₂, and dihydrolipoyl dehydrogenase known as E₃. It also requires five coenzymes namely: thiamine pyrophosphate (TPP), flavine adenine dinucleotide (NAD), coenzyme A (CoA-SH), nicotinamide adenine dinucleotide (NAD) and lipoate.

Oxidative decorbyxylation of pyruvate takes place in the pyruvate dehydrogenase complex in five steps:

1. Pyruvate reacts with TPP and is decarboxylated forming hydroxyethyl-TPP.

2. The lipoamide arm of E2 moves to the active site of E1, enabling the transfer of the acetyl group to the lipoamide.

3. The acetyl lipoamide arm of E2 moves to the active site of E2, where the acetyl group is transferred to CoA, forming acetyl-CoA and the reduced form of lipoamide.

4. The lipoamide arm moves to the active site of E3 where the reduced lipoamide is oxidized by FAD forming the active lipoamide and FADH2.

5. FADH2 is reoxidized to FAD reducing NAD+ to NADH.


Related Questions

help pls very simple

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What equipment is generally used to make lyophilized medications suitable for administering to the patient

need help with this question asap :)
-20 points!..

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the answer is d, ive had this before

how do you Calculate the molarity of 250 ml of solution in which 2.7 g of MgCl2 are dissolved

Answers

Answer:

Molar mass of MgCl2 is 95 g/mol

Mg = 24 g/mol and Cl = 35.5 ×2 = 71 g/mol

moles = mass given/ molar mass

= 2.7/95 = 0.028 mol

volume = 250/1000 = 0.25 dm3 (ml is the same as dm3)

molarity of MgCl2 = moles/volume

= 0.028/0.25

= 0.112 mol/dm3

why brain remembers picture better than words?​

Answers

Answer:

your brain processes ever detail in a picture rather than words for for example a picture of something words doesn't describe it as well as the picture could.

humans respond and process images way better then text. 60,000 times faster. our brains are just wired that way and pictures are coded more easily and can be retrieved symbolic mode , while the dual coding process using is more difficult for both ways retrieval and processing

Anyone mind answering this

Answers

Its option A: double replacement

Which of these challenges is unique to the process of designing prostheses as opposed to engineering other technologies?

- Knowing how a material will fail
- Using the engineering process
- Identifying a need for the technology
- Predicting how a technology will interact with human tissue

Answers

Answer:

predicting how a tech will interact with human tissue.

Explanation:

thats not really common except for in the medical field.

The challenge that is unique to the process of designing prostheses as opposed to engineering other technologies is Predicting how a technology will interact with human tissue. The correct option is option 4.

What is Prosthetic Design?

Prosthesis design is typically undertaken by shaping wax on a plaster replica of the patient's anatomy. Realism is predominantly achieved through the prosthetist's ability to interpret the correct location and physically recreate the anatomical shape and detail.

Prosthetic applications are an example of the intersection of design, technology and science.

Therefore, The challenge that is unique to the process of designing prostheses as opposed to engineering other technologies is Predicting how a technology will interact with human tissue. The correct option is option 4.

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list 2 underlying causes of water pollution

Answers

Answer:

industrialization and rapid human population growth.

Explanation:

Hope this helps

Answer:

Water Pollution

Explanation:

Dumping industrial waste in ocean

Accidental oil leakages

How do molecules work?

Answers

A molecule is essentially created by a collection of atoms linked by a network of bonds.

WILL BRAINLIST! NEED ANSWER!

• Why is it important to recycle metals?

A. to maintain sustainability
B. to create more tailings
C. to make sure ore remains renewable
D. to make it easier to extract ore from the ground

Answers

It’s C

Recycling metal is considered an environmentally friendly practice since it eliminates the demand for raw (ore) metal and conserves valuable natural resources

is H2O polar or non polar?

Answers

Answer:

Explanation:

H2O is a polar molecule

Answer:

polar covalent molecule

Explanation:

the unequal sharing of electrons between the atoms and the unsymmetrical shape of the molecule means that water has two pole a positive and a negative.

how many compounds can I make with sodium, hydrogen, oxygen?

will give brainliest and 100 points to the correct answer

Answers

Answer:

маны

Explanation:

Answer:

2H2 + O2 → 2H2O

Explanation:

What holds the nucleus together? Group of answer choices alpha particles strong forces electrical forces between the protons beta particles

Answers

Answer:electrical forces between the protons

Explanation: The strong nuclear force pulls together protons and neutrons in the nucleus. At very small distances only, such as those inside the nucleus, this strong force overcomes the electromagnetic force, and prevents the electrical repulsion of protons from blowing the nucleus apart.

d. The animals such as snakes and tortoises are called reptilians. Why? ​

Answers

Answer:

Explanation : Reptiles are cold blooded animals, have scales on their body (instead of hair or fur) and are usually egg laying. (certain viper types and boas give birth to live young). So that is what makes animals reptiles.

Reptiles are cold-blooded creatures that often lay eggs and have scales on their bodies rather than hair or fur. (Some types of vipers and boas give birth to live young).

Due to these reasons animals are reptiles.

What are reptiles?

Air-breathing vertebrates known as reptiles have unique skin consisting of scales, bony plates, or a combination of the two.

They comprise of tortoises, turtles, lizards, snakes, and crocodiles.

All of them periodically shed their skin's outer covering. The temperature of their environment affects how they function.

Reptiles do not maintain a steady internal body temperature, in contrast to birds and mammals.

They cannot stay warm on a chilly day without fur or feathers, and they cannot cool themselves on a hot day without sweat glands or the ability to pant. Instead, they shift as needed between the sun and the shade.

They stop moving around when the weather becomes colder.

Reptiles are cold-blooded due to their slow metabolic rate and heat-seeking habit.

Thus, it can be concluded that animals such as snakes and tortoises are called reptilians.

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Which compound contains ionic bonds?
No
No2
CaO
CO2

Answers

Sodium chloride, on the other hand, contains ions; it is an ionic compound. Ionic compounds contain ions and are held together by the attractive forces among the oppositely charged ions. Common salt (sodium chloride) is one of the best-known ionic compounds.

need answer asap ..
-20 points! asap please ..

Answers

Answer:

[tex][tex]\purple{\rule{45pt}{7pt}}\purple{\rule{45pt}{999999pt}}[tex][/tex]

Explanation:

[tex][tex]\purple{\rule{45pt}{7pt}}\purple{\rule{45pt}{999999pt}}[tex][/tex]

Based on the electron configuration of the two
atoms, predict the ratio of metal cationic (+) atom
to nonmetal anionic (-) atom in the compound.
Hydrogen 1s
Fluorine 1s22s22p5
A. 2:3
B. 1:2
C. 1:1
D. 3:2

Answers

Answer:

1 per 2 berarti a.2:3 berarti bagi bagi 1 22. 22 sama dengan 5

Name of equipments that uses in crude oil distillation?​

Answers

Explanation:

Crude oil distillation is a complex and capital-intensive process in petroleum refining. The crude oil distillation unit comprises distillation columns, pump-around loops, side strip.pers and a heat recovery system, known as the preheat train.

A force of 450 N accelerates a box across a frictionless surface at a rate of 15 m/s2. What is the mass of the box?

30 kg
6,750 kg
6,750 N
30 N

Answers

Answer: Option A) 30 kg

MARK BRAINLEIST PLSS

Answer:

30kg

Explanation:

F=ma

Force=mass×acceleration

40=m×15

m=450/15

m=30kg

Can someone help me with this please

Answers

Answer:

1.

a. Diagram A

b. Diagram A should stay still, but Diagram B should move/roll to the left.

__________________________________

2.

a. Diagram A and Diagram B are different because the object kg are different, one is 10kg and the other is 2kg.

b. Diagram B because its smaller making it lighter to move when Diagram A is 5 times larger, which will make it heavier.

__________________________________

3.

a. Diagram A and Diagram B compare because the object both equal 3kg.

b. Diagram A will have a greater acceleration because 80n > 40n

Symbol of elements. ​

Answers

Explanation:

Gold Au

Copper Cu

Iron Fe

Magnesium Mg

Hydrogen H

Helium He

Mercury Hg

Iodine I

The symbol of the elements is the element name you can look ok a periodic table to make it easier

Why do scientists use the scientific method?
A. It helps them do research that other scientists can understand.
B. It helps them ask questions that affect as many people as
possible.
C. It helps them make sure a certain question has not been asked
before.
OD. It helps them determine whether an idea is supported by evidence.
Help

Answers

Answer:

D

Explanation:

It helps determine whether an idea is supported by evidence

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when would a scientist choose to conduct a controlled experiment​

Answers

Answer:a scientist would choose to conduct a controlled experiment when it has all the necessary precautions and has the equipment to do so

Explanation:thank you

Plz mark for brainlist

Your teacher asks you to prepare 500 mL of a 2.75 molar solution of NaCl for an upcoming
laboratory experiment. Write a step-by-step procedure describing how you would carry out
this task.

Answers

To prepare 500 mL of a 2.75 molar solution of NaCl, measure 80.44 g of NaCl, place it in a 500 mL volumetric flask and fill it with water to the mark.

We'll begin by calculating the number of mole of NaCl in the solution

Volume = 500 mL = 500 / 1000 = 0.5 L Molarity = 2.75 MMole of NaCl =?

Mole = Molarity x Volume

Mole of NaCl = 2.75 × 0.5

Mole of NaCl = 1.375 mole

Next, we shall determine the mass of 1.375 mole of NaCl.

Mole of NaCl = 1.375 mole Molar mass of NaCl = 23 + 35.5 = 58.5 g/mol Mass of NaCl =?

Mass = mole × molar mass

Mass of NaCl = 1.375 × 58.5

Mass of NaCl = 80.44 g

Therefore, to prepare 500 mL of a 2.75 molar solution of NaCl, measure 80.44 g of NaCl, place it in a 500 mL volumetric flask and fill it with water to the mark.

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What is the interaction between atmosphere and biosphere

Answers

Answer:

Biosphere-Atmosphere Interactions focuses on the sources and sinks of greenhouse gases (GHGs), air pollutants, particulate matter, water, and energy between the Earth's surface and the atmosphere.

Explanation:

What is the balanced net ionic equation when aqueous solutions of Pb(NO3)2 and KBr are mixed and form a product

Answers

Answer:

KBr+Pb(NO3)2=? is an equation you can use.

Explanation:

what is involved fashion of male and female gametes to form a zygote which develops into an embryo ​

Answers

This process is known as fertilisation. Gametes contain half the number of chromosomes of all other cells in the organism. This means they are haploid . When the male and female gametes combine in fertilisation they create an embryo with the full complement of chromosomes (diploid).

Ensure you write the states of the reactants and products.
• phosphoric acid reacts with magnesium hydroxide

Answers

H3PO4 (aq) + Mg(OH)2 (s) -> Mg3(PO4)2 (s) + H2O (l)

A student reads that sodium atoms (Na) react with chlorine (Cl2) molecules to form the compound sodium chloride (NaCl). Which model should the student make to satisfy the Law of Conservation of Matter for the formation of sodium chloride, in simplest form?

Answers

Answer:

c

Explanation:

Law of Conservation of Matter for the formation of sodium chloride, in simplest form would be obeyed when 2 moles of sodium react with 1 ,mole of chlorine to form 2 moles of sodium chloride.

What is law of conservation of matter?

According to law of conservation of matter, it is evident that matter is neither created nor destroyed rather it is restored at the end of a chemical reaction .

Law of conservation of matter and energy are related as matter has mass and mass and energy are directly proportional which is indicated by the equation E=mc².Concept of conservation of matter is widely used in field of chemistry, fluid dynamics.

Law needs to be modified in accordance with laws of quantum mechanics under the principle of mass and energy equivalence.This law was proposed by Antoine Lavoisier in the year 1789.

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When thinking about genetic engineering in agriculture, which type of issue has the most direct consequences? economical issues political issues social issues environmental issues

Answers

Explanation:

It is claimed that the increases in crop productivity brought about by genetic engineering can help relieve problems faced by farmers by decreasing the losses caused by pests, disease, weeds, and other stressors (Guerinot 2000).

If 2.5 moles of PA react completely, how many
moles of P203 are formed?

Answers

Answer:

For every 2 moles of Na used, 2 moles of NaCl are produced.

Explanation:

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